The carob moth, Ectomyelois ceratoniae (Zeller) (Lepidoptera Pyralidae), is a major pest of pomegranate and its damage is economic in Iran and many parts of the world. The use of resistant cultivars could be an efficient pest management strategy against the carob moth in pomegranate orchards. In this study, the effects of eleven commercial cultivars of pomegranate (Aban Mahi, Esfahani Daneh ghermez, Gabri, Gorche Tafti, Malase Daneh Syah, Malase Yazdi, Shahvare Daneh Ghermez, Shahvare Daneh Sefid, Tabo Larze Mehr Mahi, Tafti and Toghe Gardan) were evaluated on life table parameters and biological characteristics of E. ceratoniae under the laboratory conditions: 30 ± 1°C, 60 ± 5% RH, and a photoperiod of 14: 10 (L: D) h. Also, in order to understand any possible correlation between life table parameters with some biochemical traits of pomegranate cultivars, protein and starch concentrations, total anthocyanins, flavonoids and total phenolic was determined. The results showed that, the longest duration of the egg, larval, pupal period and immature development time were on Esfahani Daneh ghermez and Malase Daneh Syah cultivars and the shortest was on Shahvare Daneh Sefid cultivar. In addition, there were significant differences among the pomegranate cultivars in immature survival rate (%), fecundity, adult longevity, net reproductive rate (R0), finite rate of increase (λ), and mean generation time (T). The highest (rm) values was observed on Shahvare Daneh Sefid (0.0893 ± 0.0041 day-1) and the lowest value was resulted from rearing of E. ceratoniae on Esfahani Daneh ghermez (0.0529 ± 0.00446 day-1). There were significant differences among the biochemical characteristics of pomegranate cultivars. Significant correlations were observed between life history parameters and biochemical traits of pomegranate cultivars. The results indicated that Shahvare Daneh Sefid cultivar was relatively susceptible pomegranate cultivar and Esfahani Daneh ghermez was the most inappropriate cultivar for feeding of E. ceratoniae, which could be useful in the development of Integrated Pest Management programs for this pest.