The excessive use of fertilizers and chemical pesticides, in addition to economic problems, entails irreparable damage to the environment and ecosystems and, increase in diseases such as cancer. Optimization refers to improving the performance of a system, a process, or a product in order to maximize its profit. The temperature and relative humidity and pesticide concentration can be important factors in the optimal use of pesticide .Vigna unguiculata bean is one of the most important cereals cultivated in the world and used as an important source of nutrition. Tetranychus urticae (Koch) is one of the most important pests of cowpea, which reduces the quality and quantity of the product. Fenazoquine from the kinazolin group has dermal and oral effects on larvae, nymph and adult stages of mites. RSM method is a set of mathematical and statistical methods used to modeling and analyze issues in which the desired response is affected by several different variables. Target of this attitude is finding the best assemblage of determine volatile agents to approach the determine responding. In this study, all laboratory studies were done using disk harvested bean leaf. After homogenization of female mites and bioassay tests, determination of the range of concentrations was performed the Design Expert software 7.00 was used to determine the optimal point of the central composite design (CCD) and the method Statistical response level (RSM) .The Results showed that the optimum conditions for Fenazoquine at temperatures of 26.01 ° C and 62.97% moisture and 527.30 microliters per 1000 cc distilled water with a satisfaction of 87% were obtained.