The mussel scale, Lepidosaphes ulmi Borkhsenius is one of the important pests in apple orchards of Iran. Due to its covering scale, controlling of the mentioned pest by using commonly used chemical pesticides is hard to achieve in apple orchards. In this research, efficacy of 7 treatments including, two doses of spirotetramat (Movento SC 10%), 0.75/1000 ml., and 1/1000 ml., with and without insecticide oil, Diazinon with insecticide oil, Chlorpyrifus methyl with insecticide oil, and a check treatment (water spraying) were evaluated for controlling of the mussel scale, according to RCBD with 4 replication in Azarbaijan-e gharbi, Esfahan, and Khorasan-e razavi provinces. Efficacy percentages of the treatments were estimated by using Henderson Tilton method, 3 - 45 days after spraying. Data ANOVA showed that there are statistically significant difference among treatments (P<0.01). Following ANOVA, mean comparison was carried out by using Duncan's multiple range tests at 5% probability level. According to the results, all the treatments with spirotetramat (Movento SC 10%) had the highest efficacy in mussel scale control compared to the others, 7 - 45 days after spraying. Mean efficacy percentage of the spirotetramat (Movento SC 10%) treatments was between 90% and 100% during the mentioned period of time depending on examined locations. According to the obtained results here, application of spirotetramat (Movento SC 10%) with dosage 0.75/1000 ml. is recommended for the chemical control of the mussel scale during the spring simultaneously with the time of crawler emergence in the apple orchards. Findings of this study will be applicable for management of the mussel scale in apple orchards.