Fusarium wilt caused by Fusarium oxysporum f.sp. melonis (Fom) is one of the most destructive diseases of melon which results in a high economic loss for the farmers. Applying chemical fungicides is the most conventional ways of controlling this disease. The effect inhibitory effect of five different fungicides (Nativo (Tebuconazole + Trifloxystrobin) WG 75%, Carbendazim (Bavistin) WP 60 %, Hexaconazole (Anvil) SC 50%, Tebuconazole (Raxil) DS 2%, Iprodione +Carbendazim (Rovral-TS) WP 52% on mycelial growth of (Fom) was studied in the present study. Fungi strains, obtained from pathology laboratory collection of Agricultural and Resources Research Center- Khorasan-Razavi. Fungus strains were cultured in a PDA medium exposed to different doses of nominated fungicides. Colony diameter measured after 7 days. Inhibitory effect of each treatment estimated comparing control treatment. The study was conducted as a completely randomized design with 21 treatments (five various fungicides, 4 different doses and control) and four replications. Results showed that, (Fom) mycelial growth inhibited by all fungicides whereas vrious fungicides and different levels of each fungicide showed different inhibitory percent on pathogen. Mycelial growth of (Fom) completely suppressed applying Iprodione +Carbendazim and Nativo at 10 ppm dose. Pathogen growth was completely inhibited by Bavistin, Anvil and Raxil at 70, 120 and 150 ppm respectively. Applying Nativo at 1 ppm dose resulted in 50 percent of inhibition while for Bavistin, Anvil and Raxil, 50% of pathogen growth inhibition observed at 10 ppm. Results showed that there was no significant difference between conventional Iprodione +Carbendazim and Tebuconazole+Trifloxystrobin in respect of preventing (Fom) mycelial growth.