The carob moth, Ectomyelois ceratoniae (Zeller) (Lepidoptera Pyralidae), is the most important and effective factor in decreasing quality and quantity of pomegranate in Iran and many tropical and subtropical regions. In this study, the effects of four various phenology stages of pomegranate (hazelnut-size stage, walnut-size stage, juicy and ripe stages in Shahvare Daneh Sefid cultivar) were evaluated on life table parameters and population growth of E. ceratoniae under the laboratory conditions: 30 ± 1°C, 60 ± 5% RH, and a photoperiod of 14: 10 (L: D) h. Also, in order to understand any possible correlation between life table parameters with some biochemical traits of pomegranate in its various phenology stages, protein and starch concentrations, total anthocyanins, flavonoids and total phenolic were determined. The results showed that, there were significant differences in immature survival rate (%), duration of the egg, larval, pupal period, immature development time, fecundity and adult longevity of E. ceratoniae in various phenology stages of pomegranate. The longest total development time was in hazelnut-size stage (38.22 ± 0.39 day) and the shortest one was in juicy stage (31.5 ± 0.31 day). Moreover, the highest net reproductive rate (R0) and intrinsic rate of increase (rm) values were observed in juicy stage (37.56 ± 6.32 female per female and 0.102 ± 0.0041 day-1, respectively) and the lowest values were resulted from rearing of E. ceratoniae in hazelnut-size stage (18.26 ± 3.52 female per female and 0.0692 ± 0.0049 day-1, respectively). There were significant differences in biochemical characteristics of pomegranate during its various phenology stages. Significant correlations were observed between life history parameters and biochemical traits of pomegranate phenology stages. The results indicated that juicy stage was relatively susceptible pomegranate stage and hazelnut-size stage was the most inappropriate stage for feeding of E. ceratoniae, which could be useful in the development of integrated pest management programs for this pest.