Parasitic weeds of the family Orobanchaceae, especially Orobanche and Phelipanche genuses, are known as the most economically damaging root parasites which effect on crop yields. In the Homozgan province, Tomato with 13000 hectars under cultivation area and 400000 tons per year, is an economically crop. Aegyptian broomrape (Phelipanche aegyptiaca pers.) is an important root parasitic weeds on tomato in various regins of Iran. In order to investigating on sulfosulfuron (Apyros WG75%) efficiency on broomrape (Phelipanche aegyptiaca L.) on tomato, an experiment was carried out in a randomized complete block design with 6 treatments and 4 replications on sunseed cultivar of tomato in Hormozgan province at 2015. Treatments were sulfosulfuron at 20, 30 and 40 g/ha and three check (weeding check, weeding check with broomrape and not weeding check). All herbicides were used 30, 40, 50 days after tomato transplanting in fields. The results of compound analysis showed that the location and treatment effects and their interaction had significant difference on density and dry weight total of broomrape and so on biomass and yield of tomato at 1% level. Average comparison of data showed that increasing the concentration of sulfosulfuron was reduced broomrape total density and dry weight and was increased tomato biomass and yield. Accordingly, sulfosulfuron at 30 g/ha had suitable control on P. aegyptiaca and had no effect on tomato plants. In kahurestan, hashtbandi and dashtsafa (several regions in hormozgan), sulfosulfuron at 30 g/ha was reduced broomrape total density 75, 80.81 and 76.93 percent and was reduced broomrape total dry weight 53.37, 58.46 and 44.77 percent and so was increased tomato yield 9297.7, 7846.8 and 7937.5 g/m2, respectively .