Main wheat is about 35% of the world's population, and by 2020 the global demand for this product is expected to be between 840 and 1050 million tonnes. Wheat septavirus leaf spot disease is one of the most important diseases of wheat, which causes a lot of damage to crops every year. Mycospharella graminicola is an aschemic fungus that acts as a major threat to the global food industry. Today, the use of resistance inducers has become a major focus, including the induction of salicylic acid. Salicylic acid is a pseudo-hormonal and endogenous compound in plants that is synthesized in plenty of stress during stress, including drought stress, salinity stress and pathogenic stress. Regarding the inefficiency of agronomic methods in effective control of the disease, the resistance of fungal isolates to systemic toxins, the use of resistant cultivars, the most economical and the best and the most environmentally friendly varieties, is the healthiest way to cope with this disease. In this study, the effect of salicylic acid as a resistance inducer on the activity of antioxidant peroxidase, catalase and ascorbate peroxidase enzymes in wheat septavirus leaf spot disease was investigated. For this purpose salicylic acid was used in two concentrations (0 and 2.0 mg / l) in spray (2-leaf stage) and 48 hours after treatment with fungus, the agent was induced. Sampling was carried out at 0, 12, 24, 48, 96 and 240 hours after infection and the activity of enzymes was investigated. The results show that pre-treatment of salicylic acid plants can increase enzymes activity and plant resistance. The purpose of this study was to induce resistance in wheat straw of Kohdasht cultivar to septurous leaf spot disease and changes in antioxidant activity in treated and control plants. The results indicated that the plants treated with 2 mM salicylic acid showed the activity level of peroxidase, catalase and ascorbate peroxidase activity (0.054, 0.068 and 0.11), respectively. The plants (both live and non-living) during their stress activate their antioxidant defense mechanism to protect themselves against the patient.