Main wheat is about 35% of the world's population, and by 2020 the global demand for this product is expected to be between 840 and 1050 million tonnes. Wheat septavirus leaf spot disease is one of the most important diseases of wheat, which causes a lot of damage to crops every year. Mycospharella graminicola is an aschemic fungus that acts as a major threat to the global food industry. Today, the use of resistance inducers has become a major focus, including the induction of salicylic acid. Salicylic acid is a pseudo-hormonal and endogenous compound in plants that is synthesized in plenty of stress during stress, including drought stress, salinity stress and pathogenic stress. Regarding the inefficiency of agronomic methods in effective control of the disease, the resistance of fungal isolates to systemic toxins, the use of resistant cultivars, the most economical and the best and the most environmentally friendly varieties, is the healthiest way to cope with this disease. In this study, The effect of salicylic acid as a resistance inducer in biochemical activities such as soluble sugars, proline and anthocyanin in wheat septorius disease was studied. For this purpose salicylic acid was used in two concentrations (0 and 2.0 mg / l) in spray (2-leaf stage) and 48 hours after treatment with fungus, the agent was induced. Sampling was performed at 0, 12, 24, 48, 96 and 240 hours after contamination and the rate of these activities was investigated. The results show that pretreatment of salicylic acid plants can increase these activities and plant resistance. The results show that pre-treatment of salicylic acid plants can increase biochemical activity and plant resistance. The purpose of this study was to induce resistance in susceptible wheat plant of Kohdasht cultivar to septurous leaf spot disease and changes in biochemical activity in treated and control plants. The results showed that the plants treated with 2 mM salicylic acid had the highest activity of soluble sugars, proline and anthocyanins (89.77, 11.67 and 5.90), respectively (72.63, 86.4 and 35/5) showed better performance. The plants (inactive and non-living), during their stress, activate their antioxidant defense mechanism to protect themselves against the patient.